Cytoplasmic projections of trophectoderm distinguish implanting from preimplanting and implantation-delayed mouse blastocysts
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چکیده
منابع مشابه
Ovarian Stimulation by Exogenous Gonadotropin Decreases the Implantation Rate and Expression of Mouse Blastocysts Integrins
Background: Integrins are heterodimeric glycoprotein receptors that regulate the interaction of cells with extracellular matrix and may have a critical role in implantation. The aim of this study was to investigate the effect of ovulation induction on the expression of α4, αv, β1, and β3 integrins in mouse blastocyst at the time of implantation. Methods: The ovarian stimulated and non-stimulate...
متن کاملRelationship between reactive oxygen species and autophagy in dormant mouse blastocysts during delayed implantation
OBJECTIVE Under estrogen deficiency, blastocysts cannot initiate implantation and enter dormancy. Dormant blastocysts live longer in utero than normal blastocysts, and autophagy has been suggested as a mechanism underlying the sustained survival of dormant blastocysts during delayed implantation. Autophagy is a cellular degradation pathway and a central component of the integrated stress respon...
متن کاملMicroRNA Let-7a and dicer are important in the activation and implantation of delayed implanting mouse embryos.
STUDY QUESTION Does Let-7a have a functional role in modulating dicer expression to activate dormant mouse blastocysts for implantation? SUMMARY ANSWER Let-7a post-transcriptionally regulates dicer expression altering microRNA expression to affect the implantation competency of the activated blastocysts. WHAT IS KNOWN ALREADY The Let-7a microRNA is up-regulated during blastocyst dormancy an...
متن کاملLineage analysis of inner cell mass and trophectoderm using microsurgically reconstituted mouse blastocysts.
The fate of mouse blastocyst tissues was examined following reconstitution of blastocysts from isolated inner cell mass (ICM) and trophectoderm differing for electrophoretic variants at the glucose phosphate isomerase (GPI-1) locus. A modified microsurgical method was used and a more sensitive enzyme assay allowed finer dissection of developing chimaeric conceptuses. In seven of nine cases, the...
متن کاملCorrelation between blastocyst oxygen consumption and trophoblast cytochrome oxidase reaction at initiation of implantation of delayed mouse blastocysts.
Delayed blastocysts had an oxygen consumption of 0-24 nl/h, while only 4 h after an oestrogen injection the respiration had increased nearly two fold, remaining at this level both 8 and 18 h after activation for implantation. The mitochondria of delayed blastocysts exhibited no positive cytochrome oxidase reaction, neither in the trophoblast nor in the embryoblasts. A few mitochondria at 8 h an...
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ژورنال
عنوان ژورنال: Reproduction
سال: 1990
ISSN: 1470-1626,1741-7899
DOI: 10.1530/jrf.0.0880031